Glutaredoxin 2 from big belly seahorse (Hippocampus abdominalis) and its potential involvement in cellular redox homeostasis and host immune responses.
Identifieur interne : 000164 ( Main/Exploration ); précédent : 000163; suivant : 000165Glutaredoxin 2 from big belly seahorse (Hippocampus abdominalis) and its potential involvement in cellular redox homeostasis and host immune responses.
Auteurs : W K M. Omeka [Corée du Sud] ; D S Liyanage [Corée du Sud] ; Hyerim Yang [Corée du Sud] ; Jehee Lee [Corée du Sud]Source :
- Fish & shellfish immunology [ 1095-9947 ] ; 2019.
Descripteurs français
- KwdFr :
- Alignement de séquences (médecine vétérinaire), Analyse de profil d'expression de gènes (médecine vétérinaire), Animaux (MeSH), Edwardsiella tarda (physiologie), Femelle (MeSH), Glutarédoxines (composition chimique), Glutarédoxines (génétique), Glutarédoxines (immunologie), Homéostasie (MeSH), Immunité innée (génétique), Infections à Enterobacteriaceae (immunologie), Infections à Enterobacteriaceae (médecine vétérinaire), Infections à streptocoques (immunologie), Infections à streptocoques (médecine vétérinaire), Lipopolysaccharides (effets indésirables), Maladies des poissons (immunologie), Mâle (MeSH), Oxydoréduction (MeSH), Phylogenèse (MeSH), Poly I-C (effets indésirables), Protéines de poisson (composition chimique), Protéines de poisson (génétique), Protéines de poisson (immunologie), Régulation de l'expression des gènes (immunologie), Smegmamorpha (génétique), Smegmamorpha (immunologie), Streptococcus iniae (physiologie), Séquence d'acides aminés (MeSH), Séquence nucléotidique (MeSH).
- MESH :
- composition chimique : Glutarédoxines, Protéines de poisson.
- effets indésirables : Lipopolysaccharides, Poly I-C.
- génétique : Glutarédoxines, Immunité innée, Protéines de poisson, Smegmamorpha.
- immunologie : Glutarédoxines, Infections à Enterobacteriaceae, Infections à streptocoques, Maladies des poissons, Protéines de poisson, Régulation de l'expression des gènes, Smegmamorpha.
- médecine vétérinaire : Alignement de séquences, Analyse de profil d'expression de gènes, Infections à Enterobacteriaceae, Infections à streptocoques.
- physiologie : Edwardsiella tarda, Streptococcus iniae.
- Animaux, Femelle, Homéostasie, Mâle, Oxydoréduction, Phylogenèse, Séquence d'acides aminés, Séquence nucléotidique.
English descriptors
- KwdEn :
- Amino Acid Sequence (MeSH), Animals (MeSH), Base Sequence (MeSH), Edwardsiella tarda (physiology), Enterobacteriaceae Infections (immunology), Enterobacteriaceae Infections (veterinary), Female (MeSH), Fish Diseases (immunology), Fish Proteins (chemistry), Fish Proteins (genetics), Fish Proteins (immunology), Gene Expression Profiling (veterinary), Gene Expression Regulation (immunology), Glutaredoxins (chemistry), Glutaredoxins (genetics), Glutaredoxins (immunology), Homeostasis (MeSH), Immunity, Innate (genetics), Lipopolysaccharides (adverse effects), Male (MeSH), Oxidation-Reduction (MeSH), Phylogeny (MeSH), Poly I-C (adverse effects), Sequence Alignment (veterinary), Smegmamorpha (genetics), Smegmamorpha (immunology), Streptococcal Infections (immunology), Streptococcal Infections (veterinary), Streptococcus iniae (physiology).
- MESH :
- chemical , adverse effects : Lipopolysaccharides, Poly I-C.
- chemical , chemistry : Fish Proteins, Glutaredoxins.
- chemical , genetics : Fish Proteins, Glutaredoxins.
- genetics : Immunity, Innate, Smegmamorpha.
- immunology : Enterobacteriaceae Infections, Fish Diseases, Fish Proteins, Gene Expression Regulation, Glutaredoxins, Smegmamorpha, Streptococcal Infections.
- physiology : Edwardsiella tarda, Streptococcus iniae.
- veterinary : Enterobacteriaceae Infections, Gene Expression Profiling, Sequence Alignment, Streptococcal Infections.
- Amino Acid Sequence, Animals, Base Sequence, Female, Homeostasis, Male, Oxidation-Reduction, Phylogeny.
Abstract
Glutaredoxins are oxidoreductases present in almost all living organisms. They belong to the thioredoxin superfamily and share the thioredoxin structure and catalytic motif. Glutaredoxin 2 has been identified as a mitochondrial protein in vertebrates. In this study, the sequence of Glutaredoxin 2 from Hippocampus abdominalis (HaGrx2) was analyzed by molecular, transcriptional, and functional assays. In-silico analysis revealed that HaGrx2 shows the highest homology with Hippocampus comes, while distinctly cluster with fish Grx2 orthologs. Tissue distribution analysis showed that HaGrx2 is ubiquitously expressed in all tissues tested, and the highest expression was observed in the brain and skin. Significant HaGrx2 transcript modulation was identified in blood and liver upon injecting bacterial and Pathogen Associated Molecular Patterns. The redox activity of HaGrx2 was revealed by Dehydroascorbic reduction and insulin disulfide reduction activity assays. Further, the deglutathionylation activity of 1 nM HaGrx2 was found to be equivalent to that of 0.84 nM HaGrx1. HaGrx2 exhibited antiapoptotic activity against H2O2-induced oxidative stress in FHM cells. Altogether, the results of this study suggest that HaGrx2 plays a role in redox homeostasis and innate immune responses in fish.
DOI: 10.1016/j.fsi.2019.09.071
PubMed: 31586678
Affiliations:
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Le document en format XML
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(MeSH)</term><term>Fish Diseases (immunology)</term><term>Fish Proteins (chemistry)</term><term>Fish Proteins (genetics)</term><term>Fish Proteins (immunology)</term><term>Gene Expression Profiling (veterinary)</term><term>Gene Expression Regulation (immunology)</term><term>Glutaredoxins (chemistry)</term><term>Glutaredoxins (genetics)</term><term>Glutaredoxins (immunology)</term><term>Homeostasis (MeSH)</term><term>Immunity, Innate (genetics)</term><term>Lipopolysaccharides (adverse effects)</term><term>Male (MeSH)</term><term>Oxidation-Reduction (MeSH)</term><term>Phylogeny (MeSH)</term><term>Poly I-C (adverse effects)</term><term>Sequence Alignment (veterinary)</term><term>Smegmamorpha (genetics)</term><term>Smegmamorpha (immunology)</term><term>Streptococcal Infections (immunology)</term><term>Streptococcal Infections (veterinary)</term><term>Streptococcus iniae (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences (médecine vétérinaire)</term><term>Analyse de profil d'expression de gènes (médecine vétérinaire)</term><term>Animaux (MeSH)</term><term>Edwardsiella tarda (physiologie)</term><term>Femelle (MeSH)</term><term>Glutarédoxines (composition chimique)</term><term>Glutarédoxines (génétique)</term><term>Glutarédoxines (immunologie)</term><term>Homéostasie (MeSH)</term><term>Immunité innée (génétique)</term><term>Infections à Enterobacteriaceae (immunologie)</term><term>Infections à Enterobacteriaceae (médecine vétérinaire)</term><term>Infections à streptocoques (immunologie)</term><term>Infections à streptocoques (médecine vétérinaire)</term><term>Lipopolysaccharides (effets indésirables)</term><term>Maladies des poissons (immunologie)</term><term>Mâle (MeSH)</term><term>Oxydoréduction (MeSH)</term><term>Phylogenèse (MeSH)</term><term>Poly I-C (effets indésirables)</term><term>Protéines de poisson (composition chimique)</term><term>Protéines de poisson (génétique)</term><term>Protéines de poisson (immunologie)</term><term>Régulation de l'expression des gènes (immunologie)</term><term>Smegmamorpha (génétique)</term><term>Smegmamorpha (immunologie)</term><term>Streptococcus iniae (physiologie)</term><term>Séquence d'acides aminés (MeSH)</term><term>Séquence nucléotidique (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Lipopolysaccharides</term><term>Poly I-C</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fish Proteins</term><term>Glutaredoxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Fish Proteins</term><term>Glutaredoxins</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Glutarédoxines</term><term>Protéines de poisson</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Lipopolysaccharides</term><term>Poly I-C</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Immunity, Innate</term><term>Smegmamorpha</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glutarédoxines</term><term>Immunité innée</term><term>Protéines de poisson</term><term>Smegmamorpha</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glutarédoxines</term><term>Infections à Enterobacteriaceae</term><term>Infections à streptocoques</term><term>Maladies des poissons</term><term>Protéines de poisson</term><term>Régulation de l'expression des gènes</term><term>Smegmamorpha</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Enterobacteriaceae Infections</term><term>Fish Diseases</term><term>Fish Proteins</term><term>Gene Expression Regulation</term><term>Glutaredoxins</term><term>Smegmamorpha</term><term>Streptococcal Infections</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Alignement de séquences</term><term>Analyse de profil d'expression de gènes</term><term>Infections à Enterobacteriaceae</term><term>Infections à streptocoques</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Edwardsiella tarda</term><term>Streptococcus iniae</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Edwardsiella tarda</term><term>Streptococcus iniae</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Enterobacteriaceae Infections</term><term>Gene Expression Profiling</term><term>Sequence Alignment</term><term>Streptococcal Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Female</term><term>Homeostasis</term><term>Male</term><term>Oxidation-Reduction</term><term>Phylogeny</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Homéostasie</term><term>Mâle</term><term>Oxydoréduction</term><term>Phylogenèse</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Glutaredoxins are oxidoreductases present in almost all living organisms. They belong to the thioredoxin superfamily and share the thioredoxin structure and catalytic motif. Glutaredoxin 2 has been identified as a mitochondrial protein in vertebrates. In this study, the sequence of Glutaredoxin 2 from Hippocampus abdominalis (HaGrx2) was analyzed by molecular, transcriptional, and functional assays. In-silico analysis revealed that HaGrx2 shows the highest homology with Hippocampus comes, while distinctly cluster with fish Grx2 orthologs. Tissue distribution analysis showed that HaGrx2 is ubiquitously expressed in all tissues tested, and the highest expression was observed in the brain and skin. Significant HaGrx2 transcript modulation was identified in blood and liver upon injecting bacterial and Pathogen Associated Molecular Patterns. The redox activity of HaGrx2 was revealed by Dehydroascorbic reduction and insulin disulfide reduction activity assays. Further, the deglutathionylation activity of 1 nM HaGrx2 was found to be equivalent to that of 0.84 nM HaGrx1. HaGrx2 exhibited antiapoptotic activity against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress in FHM cells. Altogether, the results of this study suggest that HaGrx2 plays a role in redox homeostasis and innate immune responses in fish.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31586678</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>30</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9947</ISSN><JournalIssue CitedMedium="Internet"><Volume>95</Volume><PubDate><Year>2019</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Fish & shellfish immunology</Title><ISOAbbreviation>Fish Shellfish Immunol</ISOAbbreviation></Journal><ArticleTitle>Glutaredoxin 2 from big belly seahorse (Hippocampus abdominalis) and its potential involvement in cellular redox homeostasis and host immune responses.</ArticleTitle><Pagination><MedlinePgn>411-421</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1050-4648(19)30955-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.fsi.2019.09.071</ELocationID><Abstract><AbstractText>Glutaredoxins are oxidoreductases present in almost all living organisms. They belong to the thioredoxin superfamily and share the thioredoxin structure and catalytic motif. Glutaredoxin 2 has been identified as a mitochondrial protein in vertebrates. In this study, the sequence of Glutaredoxin 2 from Hippocampus abdominalis (HaGrx2) was analyzed by molecular, transcriptional, and functional assays. In-silico analysis revealed that HaGrx2 shows the highest homology with Hippocampus comes, while distinctly cluster with fish Grx2 orthologs. Tissue distribution analysis showed that HaGrx2 is ubiquitously expressed in all tissues tested, and the highest expression was observed in the brain and skin. Significant HaGrx2 transcript modulation was identified in blood and liver upon injecting bacterial and Pathogen Associated Molecular Patterns. The redox activity of HaGrx2 was revealed by Dehydroascorbic reduction and insulin disulfide reduction activity assays. Further, the deglutathionylation activity of 1 nM HaGrx2 was found to be equivalent to that of 0.84 nM HaGrx1. HaGrx2 exhibited antiapoptotic activity against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress in FHM cells. Altogether, the results of this study suggest that HaGrx2 plays a role in redox homeostasis and innate immune responses in fish.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Omeka</LastName><ForeName>W K M</ForeName><Initials>WKM</Initials><AffiliationInfo><Affiliation>Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province, 63333, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liyanage</LastName><ForeName>D S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province, 63333, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Hyerim</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jehee</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju Self-Governing Province, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province, 63333, Republic of Korea. Electronic address: jehee@jejunu.ac.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>10</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Fish Shellfish Immunol</MedlineTA><NlmUniqueID>9505220</NlmUniqueID><ISSNLinking>1050-4648</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029941">Fish Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance></Chemical><Chemical><RegistryNumber>O84C90HH2L</RegistryNumber><NameOfSubstance UI="D011070">Poly I-C</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020609" MajorTopicYN="N">Edwardsiella tarda</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004756" MajorTopicYN="N">Enterobacteriaceae Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005393" MajorTopicYN="N">Fish Diseases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029941" MajorTopicYN="N">Fish Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054477" MajorTopicYN="N">Glutaredoxins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006706" MajorTopicYN="N">Homeostasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008070" MajorTopicYN="N">Lipopolysaccharides</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010084" MajorTopicYN="N">Oxidation-Reduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011070" MajorTopicYN="N">Poly I-C</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016415" MajorTopicYN="N">Sequence Alignment</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D023701" MajorTopicYN="N">Smegmamorpha</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013290" MajorTopicYN="N">Streptococcal Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000070058" MajorTopicYN="N">Streptococcus iniae</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Glutaredoxin</Keyword><Keyword MajorTopicYN="N">Immune responses</Keyword><Keyword MajorTopicYN="N">Redox homeostasis</Keyword><Keyword MajorTopicYN="N">Seahorse</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>06</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>09</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>09</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31586678</ArticleId><ArticleId IdType="pii">S1050-4648(19)30955-6</ArticleId><ArticleId IdType="doi">10.1016/j.fsi.2019.09.071</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Omeka, W K M" sort="Omeka, W K M" uniqKey="Omeka W" first="W K M" last="Omeka">W K M. Omeka</name></noRegion><name sortKey="Lee, Jehee" sort="Lee, Jehee" uniqKey="Lee J" first="Jehee" last="Lee">Jehee Lee</name><name sortKey="Liyanage, D S" sort="Liyanage, D S" uniqKey="Liyanage D" first="D S" last="Liyanage">D S Liyanage</name><name sortKey="Yang, Hyerim" sort="Yang, Hyerim" uniqKey="Yang H" first="Hyerim" last="Yang">Hyerim Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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